Article
Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2009
Prudkin Ludmila, Liu Diane D, Ozburn Natalie C, Sun Menghong, Behrens Carmen, Tang Ximing, Brown Kathlynn C, Bekele B Nebiyou, Moran Cesar, Wistuba Ignacio I
Abstract excerpt
Epithelial-to-mesenchymal transition is a process in which cells undergo a developmental switch from an epithelial to a mesenchymal phenotype. We investigated the role of this phenomenon in the pathogenesis and progression of adenocarcinoma and squamous cell carcinoma of the lung. Archived tissue from primary tumors (n=325), brain metastases (n=48) and adjacent bronchial epithelial specimens (n=192) were analyzed...
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