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Article

WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma.

Carcinogenesis - 1 May 2015

Long Apple, Giroux Véronique, Whelan Kelly A, Hamilton Kathryn E, Tétreault Marie-Pier, Tanaka Koji, Lee Ju-Seog, Klein-Szanto Andres J, Nakagawa Hiroshi, Rustgi Anil K

Abstract excerpt

Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25795715
DOI: 10.1093/carcin/bgv025
PMCID: PMC4498148

Genes

OTC
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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