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Article

EGFRvIII mediates hepatocellular carcinoma cell invasion by promoting S100 calcium binding protein A11 expression.

PloS one - 1 Jan 2013

Luo Xiaoying, Xie Hailong, Long Xiaolan, Zhou Min, Xu Zhibin, Shi Bizhi, Jiang Hua, Li Zonghai

Abstract excerpt

Epidermal growth factor receptor (EGFR) is frequently aberrantly expressed in cancer, and abnormal signalling downstream of this receptor contributes to tumour growth. EGFR variant III (EGFRvIII) is the most commonly altered form of EGFR and contains a truncated ligand-binding domain. Aberrant si...

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Share to Carcinoma, Hepatocellular
Share to ErbB Receptors
Share to Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to RNA, Small Interfering

Share to S100 Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 24376686
DOI: 10.1371/journal.pone.0083332
PMCID: PMC3869758

Genes

EGFR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24376686-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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