Article
Study of GT-repeat expansion in Heme oxygenase-1 gene promoter as genetic cause of male infertility.
Journal of assisted reproduction and genetics - 1 Aug 2011
Siasi Elham, Aleyasin Ahmad, Mowla Seyed Javad, Sahebkashaf Hamid
Abstract excerpt
PURPOSE: The length of GT-repeats polymorphic region in the promoter of human Heme oxygenase-1 gene (HO-1) alters the level of its transcriptional activity in response to oxidative stresses. Decreased level of HO-1 protein in the seminal plasma has been reported to be associated with oligospermia and azoospermia in male infertility. This is the first study to investigate the association between GT-repeats...
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