FUNCTIONAL EXPRESSION OF SV40 IN NORMAL HUMAN PROSTATIC EPITHELIAL AND FIBROBLASTIC CELLS - DIFFERENTIATION PATTERN OF NONTUMORIGENIC CELL-LINES

Abstract excerpt

To study mesenchymal-epithelial interactions associated with the normal and pathological human prostate, we have developed a model of well differentiated human prostate epithelial and fibroblastic cells. Normal human prostatic cells, either of epithelial or fibroblastic origins were successfully transfected with SV40 and strains with extended lifespan were selected until the crisis was reached, within 20 and 30...

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