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Article

A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis.

Developmental biology - 1 Dec 2011

Jezowska Barbara, Fernández Beatriz García, Amândio Ana Rita, Duarte Paulo, Mendes Cláudia, Brás-Pereira Catarina, Janody Florence

Abstract excerpt

E-cadherin plays a pivotal role in epithelial cell polarity, cell signalling and tumour suppression. However, how E-cadherin dysfunction promotes tumour progression is poorly understood. Here we show that the actin-capping protein heterodimer, which regulates actin filament polymerization, has a dual function on DE-cadherin in restricted Drosophila epithelia. Knocking down capping protein in the distal wing disc...

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Identifiers

PMID: 21963538
DOI: 10.1016/j.ydbio.2011.09.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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