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Genomic analysis reveals molecular characterization of CD30+ and CD30- extranodal natural killer/T-cell lymphomas (ENKTLs).

Human pathology - 1 Oct 2024

Zhang Xiaoying, Liang Ke, Chen Haiyan, Liu Long, Liu Ruirui, Wang Chunxue, Zhang Cuijuan

Abstract excerpt

Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is prevalent in the Asian population; however, little is known about its molecular characteristics. In this study, we examined the CD30 expression in ENKTLs and then performed whole exome sequencing on ten CD30+ ENKTL and CD30- ENKTL paired samples. CD30 was positive in 55.74% of the ENKTLs. Single nucleotide and insertion/deletion polymorphism analyses...

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PMID: 39187207
DOI: 10.1016/j.humpath.2024.105650

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