Article
Deregulated c-myc expression in Epstein-Barr-virus-immortalized B-cells induces altered growth properties and surface phenotype but not tumorigenicity.
International journal of cancer - 15 Mar 1990
Hotchin N A, Allday M J, Crawford D H
Abstract excerpt
Endemic Burkitt's lymphoma (eBL) is characterized by the presence of Epstein-Barr virus (EBV) and a chromosomal translocation which results in deregulation and constitutive expression of the c-myc proto-oncogene. In order to examine the role played by activation of c-myc in determining the eBL ph...
Topics
- Burkitt Lymphoma
- Cell Adhesion Molecules
- Cell Division
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Genes, Viral
- Herpesvirus 4, Human
- Humans
- Oncogenes
- Phenotype
- Proto-Oncogene Mas
- RNA, Messenger
- RNA, Viral
- Transfection