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Article

Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli.

The Journal of biological chemistry - 1 Jul 2011

Applebee M Kenyon, Joyce Andrew R, Conrad Tom M, Pettigrew Donald W, Palsson Bernhard Ø

Abstract excerpt

Herein we measure the effect of four adaptive non-synonymous mutations to the glycerol kinase (glpK) gene on catalytic function and regulation, to identify changes that correlate to increased fitness in glycerol media. The mutations significantly reduce affinity for the allosteric inhibitor fructose-1,6-bisphosphate (FBP) and formation of the tetramer, which are structurally related, in a manner that correlates...

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Identifiers

PMID: 21550976
DOI: 10.1074/jbc.M110.195305
PMCID: PMC3123082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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