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Article

A single amino acid change in Escherichia coli glycerol kinase abolishes glucose control of glycerol utilization in vivo.

Journal of bacteriology - 1 May 1996

Pettigrew D W, Liu W Z, Holmes C, Meadow N D, Roseman S

Abstract excerpt

Escherichia coli glycerol kinase (EC 2.7.1.30; ATP:glycerol 3-phosphotransferase) is a key element in glucose control of glycerol metabolism. Its catalytic activity is inhibited allosterically by the glycolytic intermediate, fructose 1,6-biphosphate, and by the phosphotransferase system phosphocarrier protein, IIIGlc (also known as IIAGlc). These inhibitors provide mechanisms by which glucose blocks glycerol...

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Identifiers

PMID: 8631672
DOI: 10.1128/jb.178.10.2846-2852.1996
PMCID: PMC178019

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