Article
Frequency of intrachromosomal homologous recombination induced by UV radiation in normally repairing and excision repair-deficient human cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
Tsujimura T, Maher V M, Godwin A R, Liskay R M, McCormick J J
Abstract excerpt
To investigate the role of DNA damage and nucleotide excision repair in intrachromosomal homologous recombination, a plasmid containing duplicated copies of the gene coding for hygromycin resistance was introduced into the genome of a repair-proficient human cell line, KMST-6, and two repair-defi...
Topics
- Blotting, Southern
- Cell Line
- Cell Survival
- Chromosomes, Human
- DNA Repair
- Dose-Response Relationship, Radiation
- Genes, Viral
- Humans
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Recombination, Genetic
- Restriction Mapping
- Simplexvirus