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Article

Glycated albumin upregulates upstream stimulatory factor 2 gene transcription in mesangial cells.

American journal of physiology. Renal physiology - 1 Jul 2010

Li Yanzhang, Wang Shuxia

Abstract excerpt

Diabetic nephropathy (DN) is the most common cause of end-stage renal failure. We previously demonstrated that a transcription factor called upstream stimulatory factor 2 (USF2) was upregulated in the kidneys from diabetic animals in vivo as well as in mesangial cells (MCs) exposed to high-glucose media in vitro. USF2 mediates glucose-induced thrombospondin 1 expression and transforming growth factor-beta...

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Identifiers

PMID: 20410211
DOI: 10.1152/ajprenal.00074.2010
PMCID: PMC2904172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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