Article
Analysis of neurogranin (NRGN) in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2011
Smith Rhodri Ll, Knight Deborah, Williams Hywel, Dwyer Sarah, Richards Alex, Kirov George, O'Donovan Michael C, Owen Michael J
Abstract excerpt
A recent study reported a genome-wide significant association between schizophrenia and rs12807809-a SNP located approximately 3 kbp upstream of the neurogranin gene (NRGN). We sought to determine if (a) NRGN contains common exonic variants or variants affecting expression (eQTLs) that could account for the association with rs12807809 and (b) there exist rare non-synonymous highly penetrant variants that could...
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