Article
Association between the 5q31.1 gene neurogenin1 and schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2007
Fanous Ayman H, Chen Xiangning, Wang Xu, Amdur Richard L, O'Neill F Anthony, Walsh Dermot, Kendler Kenneth S
Abstract excerpt
Multiple lines of evidence suggest that schizophrenia results from aberrant neurodevelopment. The neurogenin1 gene (neurog1) consists of a single 1,666 bp exon that encodes a basic helix-loop-helix (bHLH) transcription factor that causes neuronal differentiation and induces cortical and glutamatergic differentiation programs. Because of its function and its location in 5q31.1, which has been linked to...
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