Article
Predicting diabetic nephropathy using a multifactorial genetic model.
PloS one - 14 Apr 2011
Blech Ilana, Katzenellenbogen Mark, Katzenellenbogen Alexandra, Wainstein Julio, Rubinstein Ardon, Harman-Boehm Ilana, Cohen Joseph, Pollin Toni I, Glaser Benjamin
Abstract excerpt
AIMS: The tendency to develop diabetic nephropathy is, in part, genetically determined, however this genetic risk is largely undefined. In this proof-of-concept study, we tested the hypothesis that combined analysis of multiple genetic variants can improve prediction. METHODS: Based on previous reports, we selected 27 SNPs in 15 genes from metabolic pathways involved in the pathogenesis of diabetic nephropathy...
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