Article
Using a multi-staged strategy based on machine learning and mathematical modeling to predict genotype-phenotype risk patterns in diabetic kidney disease: a prospective case-control cohort analysis.
BMC nephrology - 23 Jul 2013
Leung Ross K K, Wang Ying, Ma Ronald C W, Luk Andrea O Y, Lam Vincent, Ng Maggie, So Wing Yee, Tsui Stephen K W, Chan Juliana C N
Abstract excerpt
BACKGROUND: Multi-causality and heterogeneity of phenotypes and genotypes characterize complex diseases. In a database with comprehensive collection of phenotypes and genotypes, we compared the performance of common machine learning methods to generate mathematical models to predict diabetic kidney disease (DKD). METHODS: In a prospective cohort of type 2 diabetic patients, we selected 119 subjects with DKD and...
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