Article
Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy.
PloS one - 20 Apr 2011
Li Yi-Ju, Minear Mollie A, Rimmler Jacqueline, Zhao Bei, Balajonda Elmer, Hauser Michael A, Allingham R Rand, Eghrari Allen O, Riazuddin S Amer, Katsanis Nicholas, Gottsch John D, Gregory Simon G, Klintworth Gordon K, Afshari Natalie A
Abstract excerpt
Fuchs endothelial corneal dystrophy (FECD) is a common, late-onset disorder of the corneal endothelium. Although progress has been made in understanding the genetic basis of FECD by studying large families in which the phenotype is transmitted in an autosomal dominant fashion, a recently reported genome-wide association study identified common alleles at a locus on chromosome 18 near TCF4 which confer...
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