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Article

Analysis of candidate genes ZEB1 and LOXHD1 in late-onset Fuchs' endothelial corneal dystrophy in an Indian cohort.

Ophthalmic genetics - 1 Aug 2018

Rao Bhavna S, Ansar Samdani, Arokiasamy Tharigopala, Sudhir Rachapalli R, Umashankar Vetrivel, Rajagopal Rama, Soumittra Nagasamy

Abstract excerpt

BACKGROUND: Fuchs' endothelial corneal dystrophy (FECD) is a complex degenerative disease of the corneal endothelium with genetic predisposition. Pathogenic rare variants have been identified in SLC4A11, LOXHD1, ZEB1, and AGBL1. Association of single nucleotide polymorphisms (SNPs) and CTG trinucleotide repeat expansions in the intron of TCF4 gene to FECD has been studied across multiple ethnicities. Recently,...

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Source

Identifiers

PMID: 29799290
DOI: 10.1080/13816810.2018.1474367

Genes

LOXHD1
ZEB1
AGBL1
LAMC1
TCF4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Analysis of candidate genes ZEB1 and LOXHD1 in late-onset Fuchs' endothelial corneal dystrophy in an Indian cohort.PMID 29799290Read ↗

Association of ZEB1 and TCF4 rs613872 changes with late onset Fuchs endothelial corneal dystrophy in patients from northern India.Semantic proximity Read ↗

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The genetics of Fuchs’ corneal dystrophySemantic proximity Read ↗

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophySemantic proximity Read ↗

Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study.Semantic proximity Read ↗

Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B.Semantic proximity Read ↗

Genetic screen of African Americans with Fuchs endothelial corneal dystrophy.Semantic proximity Read ↗

Mutations in LOXHD1, a recessive-deafness locus, cause dominant late-onset Fuchs corneal dystrophy.Semantic proximity Read ↗

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Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy.Semantic proximity Read ↗

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Molecular Studies of Tcf4 Gene and Correlation with Late‐Onset Fuchs Endothelial Corneal Dystrophy in the Greek Population: A Novel Cost‐Effective Diagnostic AlgorithmSemantic proximity Read ↗

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