Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus.

doi:10.1128/JVI.64.2.664-671.1990

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Article

Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus.

Journal of virology - 1 Feb 1990

de la Torre J C, Wimmer E, Holland J J

Abstract excerpt

We have carefully examined the frequency of guanidine-resistant revertants in six different clonal pools of guanidine-dependent mutants of type 1 poliovirus. The mutation frequency was (6.5 +/- 6.3) x 10(-4) (with all amino acid substitutions occurring at position 227). The minimal corrected base...

Topics

Base Sequence
Codon
Drug Resistance, Microbial
Guanidine
Guanidines
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Phenotype
Poliovirus
Viral Plaque Assay

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