Article
Molecular mechanisms of poliovirus variation and evolution.
Current topics in microbiology and immunology - 1 Jan 2006
Agol V I
Abstract excerpt
Replication of poliovirus RNA is accomplished by the error-prone viral RNA-dependent RNA polymerase and hence is accompanied by numerous mutations. In addition, genetic errors may be introduced by nonreplicative mechanisms. Resulting variability is manifested by point mutations and genomic rearrangements (e.g., deletions, insertions and recombination). After description of basic mechanisms underlying this...
Topics
- Animals
- Evolution, Molecular
- Gene Rearrangement
- Genetic Variation
- Genome, Viral
- Humans
- Point Mutation
- Poliovirus
- Recombination, Genetic
- Selection, Genetic
- Virus Replication