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Article

Cytotoxicity Associated with Artemis Overexpression After Lentiviral Vector-Mediated Gene Transfer

17 Feb 2010

Abstract excerpt

Artemis is one of the newest proteins identified in V(D)J recombination. Deficiency of functional Artemis can result in severe combined immunodeficiency (SCID). In this article by Multhaup and colleagues, the authors conduct preclinical in vitro studies examining the safety and efficacy of lentiviral-mediated delivery of Artemis in Artemis-deficient mammalian cells. Artemis is a hairpin-opening endonuclease...

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Identifiers

PMID: 20163250
DOI: 10.1089/hum.2009.162

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Cytotoxicity Associated with Artemis Overexpression After Lentiviral Vector-Mediated Gene TransferPMID 20163250Read ↗

Lentivirus Mediated Correction of Artemis-Deficient Severe Combined ImmunodeficiencySemantic proximity Read ↗

Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transferSemantic proximity Read ↗

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A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.Semantic proximity Read ↗

Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.Semantic proximity Read ↗

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A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation.Semantic proximity Read ↗

The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system.Semantic proximity Read ↗

Artemis splice defects cause atypical SCID and can be restored in vitro by an antisense oligonucleotide.Semantic proximity Read ↗

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