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Article

Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase.

Nucleic acids research - 1 Jun 2008

Yannone Steven M, Khan Imran S, Zhou Rui-Zhe, Zhou Tong, Valerie Kristoffer, Povirk Lawrence F

Abstract excerpt

Previous work showed that, in the presence of DNA-dependent protein kinase (DNA-PK), Artemis slowly trims 3'-phosphoglycolate-terminated blunt ends. To examine the trimming reaction in more detail, long internally labeled DNA substrates were treated with Artemis. In the absence of DNA-PK, Artemis...

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Identifiers

PMID: 18440975
DOI: 10.1093/nar/gkn205
PMCID: PMC2425473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18440975-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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