Article
NOC4L coordinates neuronal and pharyngeal arch development by regulating ribosome biogenesis.
Journal of molecular cell biology - 17 Jun 2026
Song Tujing, Liu Yan, Zhou Yunxiang, Li Xiaoyu, Zhang Liang, Ning Guozhu, Zhang Jingjing
Abstract excerpt
Mutations in ribosome biogenesis-related genes or functional defects in ribosomal proteins can lead to a class of autosomal genetic disorders characterized by tissue-specific defects, termed ribosomopathies. NOC4L, a critical factor in ribosome biogenesis, participates in the maturation of the 40S small ribosomal subunit. However, its functions in neural and cartilage development remain incompletely understood....
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