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Article

An enhancer within the divergent promoter of Epstein-Barr virus responds synergistically to the R and Z transactivators.

Journal of virology - 1 Jan 1990

Cox M A, Leahy J, Hardwick J M

Abstract excerpt

The EA-R and NotI repeat genes of Epstein-Barr virus (EBV) are oriented head to head and separated by a 1,000-base-pair (bp) divergent promoter region. We have identified functional domains within this divergent promoter which are important for regulation of the rightward EA-R gene. Both the R transactivator (Rta) and the Z transactivator (Zta) increase the abundance of correctly initiated EA-R transcripts. A...

Topics

Animals
Base Sequence
Cell Line
Cells, Cultured
Chromosome Deletion
Enhancer Elements, Genetic
Gene Expression Regulation, Viral
Genes, Viral
Genetic Variation
Herpesvirus 4, Human
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Promoter Regions, Genetic

Restriction Mapping

Trans-Activators

Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 2152819
DOI: 10.1128/JVI.64.1.313-321.1990
PMCID: PMC249104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2152819-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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An enhancer within the divergent promoter of Epstein-Barr virus responds synergistically to the R and Z transactivators.PMID 2152819Read ↗

The enhancer factor R of Epstein-Barr virus (EBV) Is a sequence-specific DNA binding proteinSemantic proximity Read ↗

Marked Variation in Response of Consensus Binding Elements for the Rta Protein of Epstein-Barr VirusSemantic proximity Read ↗

The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z.Semantic proximity Read ↗

Synergistic autoactivation of the Epstein-Barr virus immediate-early BRLF1 promoter by Rta and Zta.Semantic proximity Read ↗

Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator ZtaSemantic proximity Read ↗

Transcriptional interference between the EBV transcription factors EB1 and R: both DNA-binding and activation domains of EB1 are required.Semantic proximity Read ↗

B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1.Semantic proximity Read ↗

Activation of the Epstein-Barr virus DNA polymerase promoter by the BRLF1 immediate-early protein is mediated through USF and E2F.Semantic proximity Read ↗

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.Semantic proximity Read ↗

The long terminal repeat (LTR) of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2.Semantic proximity Read ↗

The Epstein-Barr virus (EBV) DNA polymerase accessory protein, BMRF1, activates the essential downstream component of the EBV oriLyt.Semantic proximity Read ↗

Essential Role of Rta in Lytic DNA Replication of Epstein-Barr VirusSemantic proximity Read ↗

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