Article
The deubiquitinating enzyme Dot4p is involved in regulating nutrient uptake.
Biochemical and biophysical research communications - 13 Apr 2001
Kahana A
Abstract excerpt
In yeast, several membrane-bound nutrient transporters have been shown to be regulated by the covalent attachment of ubiquitin, a signal for internalization and degradation. The yeast gene DOT4 encodes one of a family of enzymes which remove ubiquitin from proteins to which the peptide has been attached. Mutations in DOT4 cause a growth defect that is particularly severe when combined with mutations in nutrient...
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