Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The conserved YAGL motif in human metapneumovirus is required for higher-order cellular assemblies of the matrix protein and for virion production.

Journal of virology - 1 Jul 2011

Sabo Yosef, Ehrlich Marcelo, Bacharach Eran

Abstract excerpt

YXXL motifs in cellular and viral proteins have a variety of functions. The matrix (M) protein of the respiratory pathogen human metapneumovirus (hMPV) contains two such conserved motifs--YSKL and YAGL. We mutated these sequences to analyze their contributions to hMPV infectivity. The mutant clones were capable of intracellular replication; however, the YAGL but not YSKL mutants were defective at spreading in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Metapneumovirus

Share to Sequence Alignment

Share to Vero Cells

Share to Viral Matrix Proteins

Share to Virion

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 21525358
DOI: 10.1128/JVI.02694-10
PMCID: PMC3126496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The conserved YAGL motif in human metapneumovirus is required for higher-order cellular assemblies of the matrix protein and for virion production.PMID 21525358Read ↗

Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization.Semantic proximity Read ↗

Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensionsSemantic proximity Read ↗

Matrix protein of Akv murine leukemia virus: genetic mapping of regions essential for particle formation.Semantic proximity Read ↗

The YPLGVG sequence of the Nipah virus matrix protein is required for budding.Semantic proximity Read ↗

Specific Residues in the C-Terminal Domain of the Human Metapneumovirus Phosphoprotein Are Indispensable for Formation of Viral Replication Centers and Regulation of the Function of the Viral Polymerase ComplexSemantic proximity Read ↗

Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell SpreadSemantic proximity Read ↗

Subcellular Characterization of the Molecular Determinants of Ebola VP40 Trafficking and AssemblySemantic proximity Read ↗

Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and TranscriptionSemantic proximity Read ↗

Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus FormationSemantic proximity Read ↗

In vitro evolution of high-titer, virus-like vesicles containing a single structural proteinSemantic proximity Read ↗

L-domain flanking sequences are important for host interactions and efficient budding of vesicular stomatitis virus recombinants.Semantic proximity Read ↗

Conserved Motifs within Ebola and Marburg Virus VP40 Proteins Are Important for Stability, Localization, and Subsequent Budding of Virus-Like ParticlesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.