Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006

Yi MinKyung, Villanueva Rodrigo A, Thomas David L, Wakita Takaji, Lemon Stanley M

Abstract excerpt

Infections with hepatitis C virus (HCV) are marked by frequent viral persistence, chronic liver disease, and extraordinary viral genetic diversity. Although much has been learned about HCV since its discovery, progress has been slowed by a lack of permissive cell culture systems supporting its replication. Productive infections have been achieved recently with genotype 2a virus, but cirrhosis and liver cancer are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Liver Neoplasms

Share to RNA, Viral

Share to Tumor Cells, Cultured

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 16461899
DOI: 10.1073/pnas.0510727103
PMCID: PMC1413728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells.PMID 16461899Read ↗

Genotype 1a HCV (H77S) infection system.Semantic proximity Read ↗

Production of infectious hepatitis C virus of various genotypes in cell cultures.Semantic proximity Read ↗

Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture.Semantic proximity Read ↗

Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.Semantic proximity Read ↗

Cell culture replication of a genotype 1b hepatitis C virus isolate cloned from a patient who underwent liver transplantation.Semantic proximity Read ↗

Direct infection and replication of naturally occurring hepatitis C virus genotypes 1, 2, 3 and 4 in normal human hepatocyte cultures.Semantic proximity Read ↗

Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.Semantic proximity Read ↗

Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.Semantic proximity Read ↗

Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.Semantic proximity Read ↗

Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells.Semantic proximity Read ↗

Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1.Semantic proximity Read ↗

Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A InhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.