Article
Hypocretin levels in sporadic and familial cases of canine narcolepsy.
Neurobiology of disease - 1 Jun 2001
Ripley B, Fujiki N, Okura M, Mignot E, Nishino S
Abstract excerpt
Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy. In humans, mutations in hypocretin-related genes are rare, but cerebrospinal fluid (CSF) hypocretin-1 is undetectable in most sporadic cases. Using the canine model, we investigated ( 1 ) whether hypocretin deficiency is involved in sporadic cases and...
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