Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines.

Genome research - 1 Apr 2001

Hungs M, Fan J, Lin L, Lin X, Maki R A, Mignot E

Abstract excerpt

Narcolepsy is a sleep disorder affecting animals and humans. Exon skipping mutations of the Hypocretin/Orexin-receptor-2 (Hcrtr2) gene were identified as the cause of narcolepsy in Dobermans and Labradors. Preprohypocretin (Hcrt) knockout mice have symptoms similar to human and canine narcolepsy. In this study, 11 sporadic cases of canine narcolepsy and two additional multiplex families were investigated for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Segregation
Share to Dog Diseases
Share to Narcolepsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuropeptides

Share to Orexin Receptors

Share to Orexins

Share to Receptors, G-Protein-Coupled

Share to Receptors, Neuropeptide

Source

Identifiers

PMID: 11282968
DOI: 10.1101/gr.gr-1610r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines.PMID 11282968Read ↗

Hypocretins/orexins as integrators of physiological information: lessons from mutant animals.Semantic proximity Read ↗

The hypocretin/orexin system in health and disease.Semantic proximity Read ↗

Sleep, sleep disorders and hypocretin (orexin).Semantic proximity Read ↗

Review of pathophysiology and clinical management of narcolepsy in dogs.Semantic proximity Read ↗

Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy.Semantic proximity Read ↗

Hypocretin levels in sporadic and familial cases of canine narcolepsy.Semantic proximity Read ↗

Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers.Semantic proximity Read ↗

Hypocretin (orexin) neuropeptide precursor gene, HCRT, polymorphisms in early-onset narcolepsy with cataplexy.Semantic proximity Read ↗

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.Semantic proximity Read ↗

Animal Models of Narcolepsy: From Hypocretin Deficiency to Immune Mechanisms and Regenerative TherapiesSemantic proximity Read ↗

Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders.Semantic proximity Read ↗

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.