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Article

Robust L-type calcium current expression following heterozygous knockout of the Cav1.2 gene in adult mouse heart.

The Journal of physiology - 1 Jul 2011

Rosati Barbara, Yan Qinghong, Lee Mi Sun, Liou Shian-Ren, Ingalls Brian, Foell Jason, Kamp Timothy J, McKinnon David

Abstract excerpt

Mechanisms that contribute to maintaining expression of functional ion channels at relatively constant levels following perturbations of channel biosynthesis are likely to contribute significantly to the stability of electrophysiological systems in some pathological conditions. In order to examine the robustness of L-type calcium current expression, the response to changes in Ca²⁺ channel Cav1.2 gene dosage was...

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Identifiers

PMID: 21521762
DOI: 10.1113/jphysiol.2011.210237
PMCID: PMC3145939

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