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Article

Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.

PloS one - 14 Mar 2007

Hullin Roger, Matthes Jan, von Vietinghoff Sibylle, Bodi Ilona, Rubio Marta, D'Souza Karen, Friedrich Khan Ismail, Rottländer Dennis, Hoppe Uta C, Mohacsi Paul, Schmitteckert Eva, Gilsbach Ralf, Bünemann Moritz, Hein Lutz, Schwartz Arnold, Herzig Stefan

Abstract excerpt

BACKGROUND: Increased activity of single ventricular L-type Ca(2+)-channels (L-VDCC) is a hallmark in human heart failure. Recent findings suggest differential modulation by several auxiliary beta-subunits as a possible explanation. METHODS AND RESULTS: By molecular and functional analyses of hum...

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Identifiers

PMID: 17356701
DOI: 10.1371/journal.pone.0000292
PMCID: PMC1808423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17356701-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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