Article
Evaluation of variants in the selectin genes in age-related macular degeneration.
BMC medical genetics - 26 Apr 2011
Mullins Robert F, Skeie Jessica M, Folk James C, Solivan-Timpe Frances M, Oetting Thomas A, Huang Jian, Wang Kai, Stone Edwin M, Fingert John H
Abstract excerpt
BACKGROUND: Age-related macular degeneration (AMD) is a common disease of the elderly that leads to loss of the central visual field due to atrophic or neovascular events. Evidence from human eyes and animal models suggests an important role for macrophages and endothelial cell activation in the pathogenesis of AMD. We sought to determine whether common ancestral variants in genes encoding the selectin family of...
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