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Article

Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder.

Annals of neurology - 1 May 2011

Sundaram Senthil K, Huq Ahm M, Sun Zhen, Yu Wu, Bennett Lindsey, Wilson Benjamin J, Behen Michael E, Chugani Harry T

Abstract excerpt

Ten members of a 3-generation pedigree with 7 showing Tourette syndrome/chronic tic phenotype (TS-CTD) were evaluated with whole exome sequencing. We identified 3 novel, nonsynonymous single nucleotide variants in the MRPL3, DNAJC13, and OFCC1 genes that segregated with chronic tic phenotype. These variants were not present in 100 control subjects or in dbSNP/1000 Genomes databases. A novel variant in the 5'...

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Source

Identifiers

PMID: 21520241
DOI: 10.1002/ana.22398

Genes

DNAJC13
MRPL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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