Article
Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation.
Proceedings of the National Academy of Sciences of the United States of America - 10 May 2011
Rong Yueguang, McPhee Christina K, McPhee Christina, Deng Shuangshen, Huang Lei, Chen Lilian, Liu Mei, Tracy Kirsten, Baehrecke Eric H, Baehreck Eric H, Yu Li, Lenardo Michael J
Abstract excerpt
Autophagy is a conserved cellular process to degrade and recycle cytoplasmic components. During autophagy, lysosomes fuse with an autophagosome to form an autolysosome. Sequestered components are degraded by lysosomal hydrolases and presumably released into the cytosol by lysosomal efflux permeases. Following starvation-induced autophagy, lysosome homeostasis is restored by autophagic lysosome reformation (ALR)...
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