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The Genetics of Autophagy in Multicellular Organisms

9 Jun 2022

Abstract excerpt

Autophagy, a lysosome-mediated degradation process evolutionarily conserved from yeast to mammals, is essential for maintaining cellular homeostasis and combating diverse cellular stresses. Autophagy involves de novo synthesis of a double-membrane autophagosome, sequestration of selected cellular contents, and subsequent delivery of sequestrated contents to the vacuole (in yeasts and plants) or to lysosomes (in...

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PMID: 35679620
DOI: 10.1146/annurev-genet-022422-095608

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