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Article

Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2011

Memarzadeh Sanaz, Cai Houjian, Janzen Deanna M, Xin Li, Lukacs Rita, Riedinger Mireille, Zong Yang, DeGendt Karel, Verhoeven Guido, Huang Jiaoti, Witte Owen N

Abstract excerpt

The steroid hormone signaling axis is thought to play a central role in initiation and progression of many hormonally regulated epithelial tumors. It is unclear whether all cancer-initiating signals depend on an intact hormone receptor signaling machinery. To ascertain whether cell autonomous androgen receptor (AR) is essential for initiation of prostate intraepithelial neoplasia (PIN), the response of AR-null...

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PMID: 21518863
DOI: 10.1073/pnas.1105243108
PMCID: PMC3093518

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FGF10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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