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Article

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2013

Stoyanova Tanya, Cooper Aaron R, Drake Justin M, Liu Xian, Armstrong Andrew J, Pienta Kenneth J, Zhang Hong, Kohn Donald B, Huang Jiaoti, Witte Owen N, Goldstein Andrew S

Abstract excerpt

The relationship between the cells that initiate cancer and the cancer stem-like cells that propagate tumors has been poorly defined. In a human prostate tissue transformation model, basal cells expressing the oncogenes Myc and myristoylated AKT can initiate heterogeneous tumors. Tumors contain features of acinar-type adenocarcinoma with elevated eIF4E-driven protein translation and squamous cell carcinoma marked...

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Identifiers

PMID: 24282295
DOI: 10.1073/pnas.1320565110
PMCID: PMC3864278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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