Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism.

The Journal of biological chemistry - 17 Jun 2011

Kamani Mustafa, Mylvaganam Murugesapillai, Tian Robert, Rigat Brigitte, Binnington Beth, Lingwood Clifford

Abstract excerpt

Mammalian glycosphingolipid (GSL) precursor monohexosylceramides are either glucosyl- or galactosylceramide (GlcCer or GalCer). Most GSLs derive from GlcCer. Substitution of the GSL fatty acid with adamantane generates amphipathic mimics of increased water solubility, retaining receptor function. We have synthesized adamantyl GlcCer (adaGlcCer) and adamantyl GalCer (adaGalCer). AdaGlcCer and adaGalCer partition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Galactosidase
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycosphingolipids

Share to Hydrogen-Ion Concentration

Share to Lysosomal Storage Diseases

Share to Lysosomes

Share to Microsomes

Share to Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 21518770
DOI: 10.1074/jbc.M110.207670
PMCID: PMC3122201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism.PMID 21518770Read ↗

Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.Semantic proximity Read ↗

Glucosylceramide depletion disrupts endolysosomal function in GBA-linked Parkinson’s fibroblasts?Semantic proximity Read ↗

Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types.Semantic proximity Read ↗

Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).Semantic proximity Read ↗

Cycling Molecular Assemblies for Selective Cancer Cell Golgi DisruptionSemantic proximity Read ↗

N-glycosylation of human sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is essential for stability, secretion and activity.Semantic proximity Read ↗

Hydrophobic Man-1-P derivatives correct abnormal glycosylation in Type I congenital disorder of glycosylation fibroblasts.Semantic proximity Read ↗

The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis.Semantic proximity Read ↗

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2).Semantic proximity Read ↗

Therapeutic Applications of Imino Sugars in Lysosomal Storage DisordersSemantic proximity Read ↗

Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells.Semantic proximity Read ↗

Gla-domain mediated targeting of externalized phosphatidylserine for intracellular deliverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.