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Article

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer

1 Mar 2009

Abstract excerpt

Gefitinib (Iressa) is a specific and effective epidermal growth factor receptor inhibitor. An understanding of the downstream cellular targets of gefitinib will allow the discovery of biomarkers for predicting outcomes and monitoring anti-epidermal growth factor receptor therapies and provide information for overcoming gefitinib resistance. In this study, we investigated the role and regulation of FOXM1 in...

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PMID: 19276163
DOI: 10.1158/1535-7163.mct-08-0805

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