Article
[Perforin gene mutations in patients with acquired severe aplastic anemia].
Zhongguo shi yan xue ye xue za zhi - 1 Apr 2011
Zhang Jian, Fu Rong, Wang Jun, Li Li-Juan, Song Jia, Qu Wen, Wang Hua-Quan, Xing Li-Min, Liu Hong, Wu Yu-Hong, Guan Jin, Wang Guo-Jin, Wang Xiao-Min, Liang Yong, Ruan Er-Bao, Liu Hui, Shao Zong-Hong
Abstract excerpt
This study was aimed to explore whether the perforin gene 1 (PRF1) mutation is the basis of genetic susceptibility to pathogenesis of acquired severe aplastic anemia (SAA). DNA exon2 and exon3 of PRF1 gene in peripheral blood mononuclear cells in 31 SAA patients and 15 normal controls were amplified by PCR; the sequencing was performed by using ABI pRISM 373OXL sequencer; the mutation loci were sought through...
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