Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3.

doi:10.1093/hmg/8.2.307

Article

Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3.

Human molecular genetics - 1 Feb 1999

Kyo K, Parkes M, Takei Y, Nishimori H, Vyas P, Satsangi J, Simmons J, Nagawa H, Baba S, Jewell D, Muto T, Lathrop G M, Nakamura Y

Abstract excerpt

Ulcerative colitis (UC), a common form of inflammatory bowel disease, is a multifactorial disorder with significant genetic influence. Recently, evidence of linkage on chromosome 7q near the intestinal mucin gene MUC3 was reported by an affected sib-pair analysis. Previous reports indicate a poss...

Topics

Alleles
Colitis, Ulcerative
DNA
Gene Frequency
Humans
Intestinal Mucosa
Minisatellite Repeats
Mucin-3
Mucins
Odds Ratio
Polymorphism, Genetic

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