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Article

The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.

Molecular neurodegeneration - 9 Dec 2015

Veldman Matthew B, Rios-Galdamez Yesenia, Lu Xiao-Hong, Gu Xiaofeng, Qin Wei, Li Song, Yang X William, Lin Shuo

Abstract excerpt

BACKGROUND: Although the genetic cause for Huntington's disease (HD) has been known for over 20 years, the mechanisms that cause the neurotoxicity and behavioral symptoms of this disease are not well understood. One hypothesis is that N-terminal fragments of the HTT protein are the causative agents in HD and that peptide sequences adjacent to the poly-glutamine (Q) repeats modify its toxicity. Here we test the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26645399
DOI: 10.1186/s13024-015-0063-2
PMCID: PMC4673728

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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