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Article

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2011

Gao Su, Keung Wendy, Serra Dolors, Wang Wei, Carrasco Patricia, Casals Nuria, Hegardt Fausto G, Moran Timothy H, Lopaschuk Gary D

Abstract excerpt

Hypothalamic fatty acid metabolism is involved in central nervous system controls of feeding and energy balance. Malonyl-CoA, an intermediate of fatty acid biosynthesis, is emerging as a significant player in these processes. Notably, hypothalamic malonyl-CoA has been implicated in leptin's feeding effect. Leptin treatment increases malonyl-CoA level in the hypothalamic arcuate nucleus (Arc), and this increase is...

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Identifiers

PMID: 21508288
DOI: 10.1152/ajpregu.00092.2011
PMCID: PMC4747894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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