Article
Activation of cryptic aminoglycoside resistance in Salmonella enterica.
Molecular microbiology - 1 Jun 2011
Koskiniemi Sanna, Pränting Maria, Gullberg Erik, Näsvall Joakim, Andersson Dan I
Abstract excerpt
Aminoglycoside resistance in bacteria can be acquired by several mechanisms, including drug modification, target alteration, reduced uptake and increased efflux. Here we demonstrate that increased resistance to the aminoglycosides streptomycin and spectinomycin in Salmonella enterica can be conferred by increased expression of an aminoglycoside adenyl transferase encoded by the cryptic, chromosomally located aadA...
Topics
- Aminoglycosides
- Anti-Bacterial Agents
- Bacterial Proteins
- Drug Resistance, Bacterial
- Gene Expression Regulation, Bacterial
- Humans
- Mutation
- Salmonella Infections
- Salmonella enterica
- Streptomycin
- Transcriptional Activation
- Transferases