Article
T1846 and A/G1913 are associated with acute on chronic liver failure in patients infected with hepatitis B virus genotypes B and C.
Journal of medical virology - 1 Jun 2011
Yan Tao, Li Ke, Li Fan, Su Haibin, Mu Jinsong, Tong Shuping, Patel Mitul, Xia Jie, Wands Jack R, Wang Huifen
Abstract excerpt
The aim of this study was to determine whether mutations in the hepatitis B virus (HBV) genome are associated with the onset of acute on chronic liver failure (ACLF). For the longitudinal study, full-length HBV genomes were cloned and sequenced from four ACLF patients and compared with sequences from matching samples collected before ACLF. For the cross-sectional study, 166 serum samples were obtained, including...
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