Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.

PloS one - 1 Jan 2015

Xu Hangdi, Zhao Mingfei, Lou Guohua, Zheng Min, Cao Qingyi, Chen Zhi

Abstract excerpt

The objective of this study was to identify new viral biomarkers associated with acute on chronic liver failure (ACLF) by complete genomic sequencing of HBV. Hepatitis B virus mutations associated with ACLF were screened by Illumina high-throughput sequencing in twelve ACLF cases and twelve age-matched mild chronic hepatitis B patients, which were validated in 438 chronic hepatitis B patients (80 asymptomatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to Genomics
Share to Hepatitis B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B Core Antigens

Share to Hepatitis B Surface Antigens

Share to Hepatitis B virus

Share to High-Throughput Nucleotide Sequencing

Share to Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 25849554
DOI: 10.1371/journal.pone.0123139
PMCID: PMC4388673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.PMID 25849554Read ↗

Clinical and virological implications of A1846T and C1913A/G mutations of hepatitis B virus genome in severe liver diseases.Semantic proximity Read ↗

Human genomics of acute liver failure due to hepatitis B virus infection: an exome sequencing study in liver transplant recipientsSemantic proximity Read ↗

Evaluation of current treatment recommendations for chronic hepatitis B: a 2011 update.Semantic proximity Read ↗

Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure.Semantic proximity Read ↗

Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations.Semantic proximity Read ↗

T1846 and A/G1913 are associated with acute on chronic liver failure in patients infected with hepatitis B virus genotypes B and C.Semantic proximity Read ↗

Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinomaSemantic proximity Read ↗

Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis.Semantic proximity Read ↗

Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.Semantic proximity Read ↗

Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patientsSemantic proximity Read ↗

The association between SNPs and hepatitis B virus related acute-on-chronic liver failure.Semantic proximity Read ↗

Next-generation sequencing for the diagnosis of hepatitis B: current status and future prospects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.