Article
Proteasome modulator 9 and macrovascular pathology of T2D.
Cardiovascular diabetology - 17 Apr 2011
Gragnoli Claudia
Abstract excerpt
AIMS: Coronary artery disease (CAD) and stroke share a major linkage at the chromosome 12q24 locus. The same chromosome region entails at least a major risk gene for type 2 diabetes (T2D) within NIDDM2, the non-insulin-dependent-diabetes 2 locus. The gene of proteasome modulator 9 (PSMD9) lies in the NIDDM2 region and is implicated in diabetes in mice. PSMD9 mutations rarely cause T2D and common variants are...
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