<i>MIR29B</i> regulates expression of <i>MLLT11 (AF1Q),</i> an <i>MLL</i> fusion partner, and low <i>MIR29B expression</i> associates with adverse cytogenetics and poor overall survival in AML

Abstract excerpt

MLLT11, an MLL fusion partner, is a poor prognostic biomarker for paediatric acute myeloid leukaemia (AML), adult normal cytogenetics AML, and adult myelodysplastic syndrome. MLLT11 is highly regulated during haematopoietic progenitor differentiation and development but its regulatory mechanisms have not been defined. In this study, we demonstrate by transfection experiments that MIR29B directly regulates MLLT11...

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