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Article

Disturbed protein-protein interaction networks in metastatic melanoma are associated with worse prognosis and increased functional mutation burden.

Pigment cell & melanoma research - 1 Sept 2013

Schramm Sarah-Jane, Li Simone S, Jayaswal Vivek, Fung David C Y, Campain Anna E, Pang Chi N I, Scolyer Richard A, Yang Yee Hwa, Mann Graham J, Wilkins Marc R

Abstract excerpt

For disseminated melanoma, new prognostic biomarkers and therapeutic targets are urgently needed. The organization of protein-protein interaction networks was assessed via the transcriptomes of four independent studies of metastatic melanoma and related to clinical outcome and MAP-kinase pathway mutations (BRAF/NRAS). We also examined patient outcome-related differences in a predicted network of microRNAs and...

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Identifiers

PMID: 23738911
DOI: 10.1111/pcmr.12126

Genes

BRAF
NRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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