Article
Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease.
Cardiovascular research - 1 Apr 2017
Derangeon Mickael, Montnach Jérôme, Cerpa Cynthia Ore, Jagu Benoit, Patin Justine, Toumaniantz Gilles, Girardeau Aurore, Huang Christopher L H, Colledge William H, Grace Andrew A, Baró Isabelle, Charpentier Flavien
Abstract excerpt
AIMS: Loss-of-function mutations in SCN5A, the gene encoding NaV1.5 channel, have been associated with inherited progressive cardiac conduction disease (PCCD). We have proposed that Scn5a heterozygous knock-out (Scn5a+/-) mice, which are characterized by ventricular fibrotic remodelling with ageing, represent a model for PCCD. Our objectives were to identify the molecular pathway involved in fibrosis development...
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